SUPRANATURAL RX - Sesamin Rx Description

Sesamin Rx is a natural product that helps optimize metabolism, body composition, and health. The active ingredient, sesamin, is a naturally occurring lignan found in sesame oil. Research suggests sesamin helps promote fat metabolism, acts as a natural antioxidant, anti-inflammatory, and helps support heart, liver, kidney, and skin health.

Sesamin Rx is not a stimulant; therefore it does not cause the potential health damaging side effects often associated with other fat loss products (i.e. ephedrine, caffeine).

Metabolism & Body Composition

Research indicates sesamin stimulates PPAR alpha and CPT- two fat metabolizing systems found throughout the body. Activating these systems helps create a naturally enhanced environment for oxidizing fat. Additionally, sesamin has shown to decrease fat storage by silencing the expression of several critical lipogenic(fat storage) genes. The combined effect helps create optimum conditions to work towards and maintain a healthy body composition. (1) (2) (3) (4) (5)

Health and Anti-Aging

Sesamin Rx may also be remarkably beneficial to ones health. Recent research has cited oxidative stress and inflammation to be major players in the aging process and disease. Through sesamin's high efficacy as a natural antioxidant and anti-inflammatory, sesamin protects the body during periods of stress.

Finally, studies show sesamin supports cardiovascular health by lowering triglycerides (blood fats), VLDL cholesterol (bad cholesterol), and increasing HDL (good cholesterol). (6) (7) (8) (9) (10) (11) (12) (13)

SOURCES

(1) Kushiro M, Masaoka T, Hageshita S, Takahashi Y, Ide T, Sugano M. Comparative effect of sesamin and episesamin on the activity and gene expression of enzymes in fatty acid oxidation and synthesis in rat liver. J Nutr Biochem. 2002 May;13(5):289-295.

(2) Ide T, et.al, Sesamin, a sesame lignan, decreases fatty acid synthesis in rat liver accompanying the down-regulation of sterol regulatory element binding protein-1. Biochim Biophys Acta. 2001 Nov 30;1534(1):1-13.

(3) Hirose N, et al, Inhibition of cholesterol absorption and synthesis in rats by sesamin. J Lipid Res. 1991 Apr;32(4):629-38.

(4) Waterman IJ, Zammit VA. Differential effects of fenofibrate or simvastatin treatment of rats on hepatic microsomal overt and latent diacylglycerol acyltransferase activities. Diabetes. 2002 Jun;51(6):1708-13.

(5) Fukuda N, et al, Effect of dietary sesamin on metabolic fate of an exogenous linolelaidic acid in perfused rat liver. J Nutr Sci Vitaminol (Tokyo). 1999 Aug;45(4):437-48.

(6) Nakabayashi A, et al, Alpha-Tocopherol enhances the hypocholesterolemic action of sesamin in rats. Int J Vitam Nutr Res. 1995;65(3):162-8.

(7) Ogawa H, et al, Sesame lignans modulate cholesterol metabolism in the stroke-prone spontaneously hypertensive rat. Clin Exp Pharmacol Physiol Suppl. 1995 Dec;22(1):S310-2.

(8) Suja KP, et al, Free radical scavenging behavior of antioxidant compounds of sesame (sesamum indicum L.) in DPPH(*) system. : J Agric Food Chem. 2004 Feb 25;52(4):912-5.

(9) Utsunomiya T, et al, Antioxidant and anti-inflammatory effects of a diet supplemented with sesamin on hepatic ischemia-reperfusion injury in rats. Hepatogastroenterology. 2003 Sep-Oct;50(53):1609-13.

(10) Nakano D, et al, Antihypertensive effect of sesamin. IV. Inhibition of vascular superoxide production by sesamin. Biol Pharm Bull. 2002 Sep;25(9):1247-9.

(11) Matsumura Y, et al, Antihypertensive effect of sesamin. III. Protection against development and maintenance of hypertension in stroke-prone spontaneously hypertensive rats. Biol Pharm Bull. 1998 May;21(5):469-73.

(12) Kita S, et al, Antihypertensive effect of sesamin. II. Protection against two-kidney, one-clip renal hypertension and cardiovascular hypertrophy. Biol Pharm Bull. 1995 Sep;18(9):1283-5.

(13) Akimoto K, et al, Protective effects of sesamin against liver damage caused by alcohol or carbon tetrachloride in rodents. Ann Nutr Metab. 1993;37(4):218-24.